An Integrated Strategy Reveals Complex Glycosylation of Erythropoietin Using Mass Spectrometry

The characterization of therapeutic glycoproteins is challenging due to the structural heterogeneity of the therapeutic protein glycosylation. This study presents an in-depth analytical strategy for glycosylation of first-generation erythropoietin (epoetin beta), including a developed mass spectrome...

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Vydané v:	Journal of proteome research Ročník 20; číslo 7; s. 3654
Hlavní autori:	Guan, Yudong, Zhang, Min, Gaikwad, Manasi, Voss, Hannah, Fazel, Ramin, Ansari, Samira, Shen, Huali, Wang, Jigang, Schlüter, Hartmut
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 02.07.2021
Predmet:	Chromatography, Liquid Erythropoietin Glycopeptides Glycosylation Polysaccharides Tandem Mass Spectrometry glycosylation mass spectrometry Python scripts glycoinformatics bottom-up erythropoietin
ISSN:	1535-3907, 1535-3907
On-line prístup:	Zistit podrobnosti o prístupe
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