Effect of Systemic Inflammatory Response to SARS-CoV-2 on Lopinavir and Hydroxychloroquine Plasma Concentrations

Coronavirus disease 2019 (COVID-19) leads to inflammatory cytokine release, which can downregulate the expression of metabolizing enzymes. This cascade affects drug concentrations in the plasma. We investigated the association between lopinavir (LPV) and hydroxychloroquine (HCQ) plasma concentration...

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Veröffentlicht in:	Antimicrobial agents and chemotherapy Jg. 64; H. 9
Hauptverfasser:	Marzolini, Catia, Stader, Felix, Stoeckle, Marcel, Franzeck, Fabian, Egli, Adrian, Bassetti, Stefano, Hollinger, Alexa, Osthoff, Michael, Weisser, Maja, Gebhard, Caroline E, Baettig, Veronika, Geenen, Julia, Khanna, Nina, Tschudin-Sutter, Sarah, Mueller, Daniel, Hirsch, Hans H, Battegay, Manuel, Sendi, Parham
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 20.08.2020
Schlagworte:	Adult Aged Aged, 80 and over Antibodies, Monoclonal, Humanized - therapeutic use Antiviral Agents - blood Antiviral Agents - pharmacokinetics Antiviral Agents - pharmacology Betacoronavirus - drug effects Betacoronavirus - immunology Betacoronavirus - pathogenicity Biomarkers - blood C-Reactive Protein - metabolism Coronavirus Infections - drug therapy Coronavirus Infections - immunology Coronavirus Infections - mortality Coronavirus Infections - virology COVID-19 Cytokine Release Syndrome - drug therapy Cytokine Release Syndrome - immunology Cytokine Release Syndrome - mortality Cytokine Release Syndrome - virology Drug Administration Schedule Drug Combinations Female Hospitals, University Humans Hydroxychloroquine - blood Hydroxychloroquine - pharmacokinetics Hydroxychloroquine - pharmacology Length of Stay - statistics & numerical data Lopinavir - blood Lopinavir - pharmacokinetics Lopinavir - pharmacology Male Middle Aged Pandemics Pneumonia, Viral - drug therapy Pneumonia, Viral - immunology Pneumonia, Viral - mortality Pneumonia, Viral - virology Retrospective Studies Ritonavir - blood Ritonavir - pharmacokinetics Ritonavir - pharmacology SARS-CoV-2 Severity of Illness Index Survival Analysis COVID-19 hydroxychloroquine inflammation lopinavir-ritonavir levels
ISSN:	1098-6596, 1098-6596
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