Carbapenemase-Producing Klebsiella pneumoniae, a Key Pathogen Set for Global Nosocomial Dominance

The management of infections due to Klebsiella pneumoniae has been complicated by the emergence of antimicrobial resistance, especially to carbapenems. Resistance to carbapenems in K. pneumoniae involves multiple mechanisms, including the production of carbapenemases (e.g., KPC, NDM, VIM, OXA-48-lik...

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Veröffentlicht in:	Antimicrobial agents and chemotherapy Jg. 59; H. 10; S. 5873
Hauptverfasser:	Pitout, Johann D D, Nordmann, Patrice, Poirel, Laurent
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 01.10.2015
Schlagworte:	Anti-Bacterial Agents - pharmacology Bacterial Proteins - genetics Bacterial Proteins - metabolism beta-Lactam Resistance - genetics beta-Lactamases - genetics beta-Lactamases - metabolism Carbapenems - pharmacology Clone Cells Conjugation, Genetic Cross Infection - drug therapy Cross Infection - epidemiology Cross Infection - microbiology DNA Transposable Elements Gene Expression Regulation, Bacterial Humans Klebsiella Infections - drug therapy Klebsiella Infections - epidemiology Klebsiella Infections - microbiology Klebsiella pneumoniae - drug effects Klebsiella pneumoniae - enzymology Klebsiella pneumoniae - genetics Klebsiella pneumoniae - pathogenicity Plasmids - chemistry Plasmids - metabolism Porins - deficiency Porins - genetics Recombination, Genetic
ISSN:	1098-6596, 1098-6596
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