mSphere of Influence: Diagnosis of antifungal tolerance and persistence

Lei Chen works in the field of clinical diagnosis of antifungal tolerance and persistence. In this mSphere of Influence, he reflects on how the papers "Antifungal tolerance is a subpopulation effect distinct from resistance and is associated with persistent candidemia" by A. Rosenberg, I....

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Bibliographic Details
Published in:mSphere Vol. 10; no. 8; p. e0002925
Main Author: Chen, Lei
Format: Journal Article
Language:English
Published: United States American Society for Microbiology 26.08.2025
Subjects:
Antifungal agents
Antifungal Agents - pharmacology
antifungal persistence
antifungal tolerance
Biomarkers
Candida - drug effects
Candidemia
Candidemia - diagnosis
Candidemia - drug therapy
Candidemia - microbiology
Clinical Microbiology
Clinical outcomes
Commentary
Diagnosis
Drug resistance
Drug Resistance, Fungal
Fungal infections
fungal single cell sequencing
Fungi
Genes
Humans
Internalization
Kinases
Macrophages
Microbial Sensitivity Tests
Mutation
Pathogens
Public health
fungal single cell sequencing
diagnosis
antifungal persistence
antifungal tolerance
ISSN:2379-5042, 2379-5042
Online Access:Get full text
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Summary:Lei Chen works in the field of clinical diagnosis of antifungal tolerance and persistence. In this mSphere of Influence, he reflects on how the papers "Antifungal tolerance is a subpopulation effect distinct from resistance and is associated with persistent candidemia" by A. Rosenberg, I. V. Ene, M. Bibi, S. Zakin, et al. (Nat Commun 9:2470, 2018, https://doi.org/10.1038/s41467-018-04926-x) and "Macrophage internalization creates a multidrug-tolerant fungal persister reservoir and facilitates the emergence of drug resistance" by A. Arastehfar, F. Daneshnia, N. Cabrera, S. Penalva-Lopez, et al. (Nat Commun 14:1183, 2023, https://doi.org/10.1038/s41467-023-36882-6) impacted his work on the development of diagnostic methods for antifungal tolerance and persistence.
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The author declares no conflict of interest.
ISSN:2379-5042
2379-5042
DOI:10.1128/msphere.00029-25