Metabolomic Profile of Aggressive Meningiomas by Using High-Resolution Magic Angle Spinning Nuclear Magnetic Resonance

Meningiomas are in most cases benign brain tumors. The WHO 2016 classification defines three grades of meningiomas. This classification had a prognosis value because grade III meningiomas have a worse prognosis value compared to grades I and II meningiomas. However, some benign or atypical meningiom...

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Vydáno v:Journal of proteome research Ročník 19; číslo 1; s. 292
Hlavní autoři: Bender, Laura, Somme, François, Ruhland, Elisa, Cicek, A Ercüment, Bund, Caroline, Namer, Izzie Jacques
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States 03.01.2020
Témata:
Amino Acids - analysis
Amino Acids - metabolism
Biopsy
Brain Neoplasms - metabolism
Brain Neoplasms - surgery
Cell Proliferation
Humans
Ki-67 Antigen - metabolism
Magnetic Resonance Spectroscopy - methods
Meningioma - metabolism
Meningioma - pathology
Meningioma - surgery
Metabolomics - methods
meningioma
ex vivo spectrometry
HRMAS NMR
metabolic signature
ISSN:1535-3907, 1535-3907
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Shrnutí:Meningiomas are in most cases benign brain tumors. The WHO 2016 classification defines three grades of meningiomas. This classification had a prognosis value because grade III meningiomas have a worse prognosis value compared to grades I and II meningiomas. However, some benign or atypical meningiomas can have a clinical aggressive behavior. There are currently no reliable markers which allow distinguishing between the meningiomas with a good prognosis and those which may recur. High-resolution magic angle spinning (HRMAS) spectrometry is a noninvasive method able to determine the metabolite profile of a tissue sample. We retrospectively analyzed 62 meningioma samples by using HRMAS spectrometry (43 metabolites). We described a metabolic profile defined by a high concentration for acetate, threonine, -acetyl-lysine, hydroxybutyrate, myoinositol, ascorbate, scylloinositol, and total choline and a low concentration for aspartate, glucose, isoleucine, valine, adenosine, arginine, and alanine. This metabolomic signature was associated with poor prognosis histological markers [Ki-67 ≥ 40%, high histological grade and negative progesterone receptor (PR) expression]. We also described a similar metabolomic spectrum between grade III and grade I meningiomas. Moreover, all grade I meningiomas with a low Ki-67 expression and a positive PR expression did not have the same metabolomic profile. Metabolomic analysis could be used to determine an aggressive meningioma in order to discuss a personalized treatment. Further studies are needed to confirm these results and to correlate this metabolic profile with survival data.
Bibliografie:ObjectType-Article-1
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ISSN:1535-3907
1535-3907
DOI:10.1021/acs.jproteome.9b00521