Revisiting the relationship between autism and schizophrenia: toward an integrated neurobiology

Schizophrenia and autism have been linked since their earliest descriptions. Both are disorders of cerebral specialization originating in the embryonic period. Genetic, molecular, and cytologic research highlights a variety of shared contributory mechanisms that may lead to patterns of abnormal conn...

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Veröffentlicht in:Annual review of clinical psychology Jg. 9; S. 555
Hauptverfasser: de Lacy, Nina, King, Bryan H
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States 01.01.2013
Schlagworte:
Autistic Disorder - etiology
Autistic Disorder - genetics
Autistic Disorder - physiopathology
Brain - growth & development
Brain - metabolism
Brain - physiopathology
Humans
Schizophrenia - etiology
Schizophrenia - genetics
Schizophrenia - physiopathology
ISSN:1548-5951, 1548-5951
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Zusammenfassung:Schizophrenia and autism have been linked since their earliest descriptions. Both are disorders of cerebral specialization originating in the embryonic period. Genetic, molecular, and cytologic research highlights a variety of shared contributory mechanisms that may lead to patterns of abnormal connectivity arising from altered development and topology. Overt behavioral pathology likely emerges during or after neurosensitive periods in which resource demands overwhelm system resources and the individual's ability to compensate using interregional activation fails. We are at the threshold of being able to chart autism and schizophrenia from the inside out. In so doing, the door is opened to the consideration of new therapeutics that are developed based upon molecular, synaptic, and systems targets common to both disorders.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
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ISSN:1548-5951
1548-5951
DOI:10.1146/annurev-clinpsy-050212-185627