Coinhibitory Pathways in Immunotherapy for Cancer

The immune system is capable of recognizing tumors and eliminates many early malignant cells. However, tumors evolve to evade immune attack, and the tumor microenvironment is immunosuppressive. Immune responses are regulated by a number of immunological checkpoints that promote protective immunity a...

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Vydané v:Annual review of immunology Ročník 34; s. 539
Hlavní autori: Baumeister, Susanne H, Freeman, Gordon J, Dranoff, Glenn, Sharpe, Arlene H
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: United States 20.05.2016
Predmet:
Animals
Antibodies, Monoclonal - therapeutic use
B7-H1 Antigen - immunology
CTLA-4 Antigen - immunology
Humans
Immunotherapy - methods
Immunotherapy - trends
Lymphocyte Activation - drug effects
Neoplasms - immunology
Neoplasms - therapy
Programmed Cell Death 1 Receptor - immunology
T-Lymphocytes - immunology
Tumor Escape
Tumor Microenvironment
PD-L1
CTLA-4
tumor immunity
PD-1
cancer immunotherapy
ISSN:1545-3278, 1545-3278
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Popis
Shrnutí:The immune system is capable of recognizing tumors and eliminates many early malignant cells. However, tumors evolve to evade immune attack, and the tumor microenvironment is immunosuppressive. Immune responses are regulated by a number of immunological checkpoints that promote protective immunity and maintain tolerance. T cell coinhibitory pathways restrict the strength and duration of immune responses, thereby limiting immune-mediated tissue damage, controlling resolution of inflammation, and maintaining tolerance to prevent autoimmunity. Tumors exploit these coinhibitory pathways to evade immune eradication. Blockade of the PD-1 and CTLA-4 checkpoints is proving to be an effective and durable cancer immunotherapy in a subset of patients with a variety of tumor types, and additional combinations are further improving response rates. In this review we discuss the immunoregulatory functions of coinhibitory pathways and their translation to effective immunotherapies for cancer.
Bibliografia:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
content type line 23
ISSN:1545-3278
1545-3278
DOI:10.1146/annurev-immunol-032414-112049