Molecular Mechanisms of Iron and Heme Metabolism

An abundant metal in the human body, iron is essential for key biological pathways including oxygen transport, DNA metabolism, and mitochondrial function. Most iron is bound to heme but it can also be incorporated into iron-sulfur clusters or bind directly to proteins. Iron's capacity to cycle...

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Veröffentlicht in:Annual review of nutrition Jg. 42; S. 311
Hauptverfasser: Dutt, Sohini, Hamza, Iqbal, Bartnikas, Thomas Benedict
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States 22.08.2022
Schlagworte:
Biological Transport
Heme - metabolism
Homeostasis - physiology
Humans
Iron - metabolism
Mitochondria - metabolism
tetrapyrrole
iron
metabolism
porphyrin
heme
trafficking
ISSN:1545-4312, 1545-4312
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Zusammenfassung:An abundant metal in the human body, iron is essential for key biological pathways including oxygen transport, DNA metabolism, and mitochondrial function. Most iron is bound to heme but it can also be incorporated into iron-sulfur clusters or bind directly to proteins. Iron's capacity to cycle between Fe and Fe contributes to its biological utility but also renders it toxic in excess. Heme is an iron-containing tetrapyrrole essential for diverse biological functions including gas transport and sensing, oxidative metabolism, and xenobiotic detoxification. Like iron, heme is essential yet toxic in excess. As such, both iron and heme homeostasis are tightly regulated. Here we discuss molecular and physiologic aspects of iron and heme metabolism. We focus on dietary absorption; cellular import; utilization; and export, recycling, and elimination, emphasizing studies published in recent years. We end with a discussion on current challenges and needs in the field of iron and heme biology.
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ObjectType-Feature-2
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ISSN:1545-4312
1545-4312
DOI:10.1146/annurev-nutr-062320-112625