Psychological outcomes in advanced cancer patients after receiving genomic tumor profiling results
Comprehensive tumor genomic profiling (CGP) offers hope for personalized treatment for cancer patients when other treatment options have been exhausted. However, receipt of nonactionable or ambiguous results could be an ongoing source of distress. We investigated patterns of hope, anxiety, depressio...
Gespeichert in:
| Veröffentlicht in: | Health psychology Jg. 41; H. 6; S. 396 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , |
| Format: | Journal Article |
| Sprache: | Englisch |
| Veröffentlicht: |
United States
01.06.2022
|
| ISSN: | 1930-7810, 1930-7810 |
| Online-Zugang: | Weitere Angaben |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| Abstract | Comprehensive tumor genomic profiling (CGP) offers hope for personalized treatment for cancer patients when other treatment options have been exhausted. However, receipt of nonactionable or ambiguous results could be an ongoing source of distress. We investigated patterns of hope, anxiety, depression, and CGP-specific anxiety in advanced cancer patients after receiving CGP results and 2-3 months later.
Participants were enrolled in a longitudinal psychosocial substudy, embedded in the Molecular Screening and Therapeutics Program, and had advanced solid cancers of any histological type with sufficient and accessible tissue for CGP. At T0 (before receiving CGP results), 1,431 participants completed sociodemographic, disease and psychosocial measures. At T1 (1-4 weeks after receiving CGP results) and T2 (2-3 months post-T1), 374 participants completed psychological outcome measures. Predictors of outcomes at T2 were identified using multinomial logistic regression.
Approximately 75% of participants did not experience significant hopelessness or distress at T1 and T2. Hope decreased by T2, yet general anxiety and CGP-specific anxiety also decreased. Receiving actionable results did not impact psychological outcomes at T2. At T2, lower hope, and higher anxiety, depression and CGP-specific anxiety were associated with lower self-efficacy. Psychological and demographic factors (age, socioeconomic status, language, medical occupation, urban living, family history of cancer) independently predicted one or more psychological trajectories. Worse health status and perceived susceptibility to cancer progression predicted hope and anxiety trajectories.
Further research on interventions to best support patients undergoing CGP with high anxiety, hopelessness, fear of cancer progression, and poorer health is urgently needed. (PsycInfo Database Record (c) 2022 APA, all rights reserved). |
|---|---|
| AbstractList | Comprehensive tumor genomic profiling (CGP) offers hope for personalized treatment for cancer patients when other treatment options have been exhausted. However, receipt of nonactionable or ambiguous results could be an ongoing source of distress. We investigated patterns of hope, anxiety, depression, and CGP-specific anxiety in advanced cancer patients after receiving CGP results and 2-3 months later.
Participants were enrolled in a longitudinal psychosocial substudy, embedded in the Molecular Screening and Therapeutics Program, and had advanced solid cancers of any histological type with sufficient and accessible tissue for CGP. At T0 (before receiving CGP results), 1,431 participants completed sociodemographic, disease and psychosocial measures. At T1 (1-4 weeks after receiving CGP results) and T2 (2-3 months post-T1), 374 participants completed psychological outcome measures. Predictors of outcomes at T2 were identified using multinomial logistic regression.
Approximately 75% of participants did not experience significant hopelessness or distress at T1 and T2. Hope decreased by T2, yet general anxiety and CGP-specific anxiety also decreased. Receiving actionable results did not impact psychological outcomes at T2. At T2, lower hope, and higher anxiety, depression and CGP-specific anxiety were associated with lower self-efficacy. Psychological and demographic factors (age, socioeconomic status, language, medical occupation, urban living, family history of cancer) independently predicted one or more psychological trajectories. Worse health status and perceived susceptibility to cancer progression predicted hope and anxiety trajectories.
Further research on interventions to best support patients undergoing CGP with high anxiety, hopelessness, fear of cancer progression, and poorer health is urgently needed. (PsycInfo Database Record (c) 2022 APA, all rights reserved). Comprehensive tumor genomic profiling (CGP) offers hope for personalized treatment for cancer patients when other treatment options have been exhausted. However, receipt of nonactionable or ambiguous results could be an ongoing source of distress. We investigated patterns of hope, anxiety, depression, and CGP-specific anxiety in advanced cancer patients after receiving CGP results and 2-3 months later.BACKGROUNDComprehensive tumor genomic profiling (CGP) offers hope for personalized treatment for cancer patients when other treatment options have been exhausted. However, receipt of nonactionable or ambiguous results could be an ongoing source of distress. We investigated patterns of hope, anxiety, depression, and CGP-specific anxiety in advanced cancer patients after receiving CGP results and 2-3 months later.Participants were enrolled in a longitudinal psychosocial substudy, embedded in the Molecular Screening and Therapeutics Program, and had advanced solid cancers of any histological type with sufficient and accessible tissue for CGP. At T0 (before receiving CGP results), 1,431 participants completed sociodemographic, disease and psychosocial measures. At T1 (1-4 weeks after receiving CGP results) and T2 (2-3 months post-T1), 374 participants completed psychological outcome measures. Predictors of outcomes at T2 were identified using multinomial logistic regression.METHODParticipants were enrolled in a longitudinal psychosocial substudy, embedded in the Molecular Screening and Therapeutics Program, and had advanced solid cancers of any histological type with sufficient and accessible tissue for CGP. At T0 (before receiving CGP results), 1,431 participants completed sociodemographic, disease and psychosocial measures. At T1 (1-4 weeks after receiving CGP results) and T2 (2-3 months post-T1), 374 participants completed psychological outcome measures. Predictors of outcomes at T2 were identified using multinomial logistic regression.Approximately 75% of participants did not experience significant hopelessness or distress at T1 and T2. Hope decreased by T2, yet general anxiety and CGP-specific anxiety also decreased. Receiving actionable results did not impact psychological outcomes at T2. At T2, lower hope, and higher anxiety, depression and CGP-specific anxiety were associated with lower self-efficacy. Psychological and demographic factors (age, socioeconomic status, language, medical occupation, urban living, family history of cancer) independently predicted one or more psychological trajectories. Worse health status and perceived susceptibility to cancer progression predicted hope and anxiety trajectories.RESULTSApproximately 75% of participants did not experience significant hopelessness or distress at T1 and T2. Hope decreased by T2, yet general anxiety and CGP-specific anxiety also decreased. Receiving actionable results did not impact psychological outcomes at T2. At T2, lower hope, and higher anxiety, depression and CGP-specific anxiety were associated with lower self-efficacy. Psychological and demographic factors (age, socioeconomic status, language, medical occupation, urban living, family history of cancer) independently predicted one or more psychological trajectories. Worse health status and perceived susceptibility to cancer progression predicted hope and anxiety trajectories.Further research on interventions to best support patients undergoing CGP with high anxiety, hopelessness, fear of cancer progression, and poorer health is urgently needed. (PsycInfo Database Record (c) 2022 APA, all rights reserved).CONCLUSIONFurther research on interventions to best support patients undergoing CGP with high anxiety, hopelessness, fear of cancer progression, and poorer health is urgently needed. (PsycInfo Database Record (c) 2022 APA, all rights reserved). |
| Author | Thomas, David M Butow, Phyllis Vatter, Sabina Napier, Christine E Bartley, Nicci Meiser, Bettina Schlub, Timothy E Biesecker, Barbara B Best, Megan C Juraskova, Ilona Ballinger, Mandy L Goldstein, David |
| Author_xml | – sequence: 1 givenname: Sabina orcidid: 0000-0001-8512-0121 surname: Vatter fullname: Vatter, Sabina organization: Psycho-Oncology Co-operative Research Group (PoCoG), School of Psychology, Faculty of Science, University of Sydney – sequence: 2 givenname: Timothy E orcidid: 0000-0001-7746-9649 surname: Schlub fullname: Schlub, Timothy E organization: Sydney School of Public Health, Faculty of Medicine and Health, University of Sydney – sequence: 3 givenname: Christine E orcidid: 0000-0001-8009-7735 surname: Napier fullname: Napier, Christine E organization: Cancer Theme, Garvan Institute of Medical Research, St Vincents Hospital – sequence: 4 givenname: Megan C orcidid: 0000-0003-1570-8872 surname: Best fullname: Best, Megan C organization: Psycho-Oncology Co-operative Research Group (PoCoG), School of Psychology, Faculty of Science, University of Sydney – sequence: 5 givenname: Nicci orcidid: 0000-0001-9052-1616 surname: Bartley fullname: Bartley, Nicci organization: Psycho-Oncology Co-operative Research Group (PoCoG), School of Psychology, Faculty of Science, University of Sydney – sequence: 6 givenname: Ilona orcidid: 0000-0001-9396-4113 surname: Juraskova fullname: Juraskova, Ilona organization: Centre for Medical Psychology and Evidence-Based Decision-Making (CeMPED), School of Psychology, Faculty of Science, University of Sydney – sequence: 7 givenname: Bettina orcidid: 0000-0002-5086-0784 surname: Meiser fullname: Meiser, Bettina organization: Psychosocial Research Group, Prince of Wales Clinical School, University of New South Wales – sequence: 8 givenname: Mandy L orcidid: 0000-0002-9706-0514 surname: Ballinger fullname: Ballinger, Mandy L organization: Cancer Theme, Garvan Institute of Medical Research, St Vincents Hospital – sequence: 9 givenname: Barbara B orcidid: 0000-0001-9665-8963 surname: Biesecker fullname: Biesecker, Barbara B organization: Center for Newborn Screening, Ethics, and Disability Studies, RTI International – sequence: 10 givenname: David orcidid: 0000-0001-6142-3291 surname: Goldstein fullname: Goldstein, David organization: Department of Medical Oncology, Prince of Wales Hospital – sequence: 11 givenname: David M orcidid: 0000-0002-2527-5428 surname: Thomas fullname: Thomas, David M organization: Cancer Theme, Garvan Institute of Medical Research, St Vincents Hospital – sequence: 12 givenname: Phyllis orcidid: 0000-0003-3562-6954 surname: Butow fullname: Butow, Phyllis organization: Psycho-Oncology Co-operative Research Group (PoCoG), School of Psychology, Faculty of Science, University of Sydney |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/35604703$$D View this record in MEDLINE/PubMed |
| BookMark | eNpNkEtLAzEUhYNU7EM3_gDJ0s1oHp1MZinFFxR0oeshydy0kZmkTjKF_ntTrODq3Hv4ONxz52jigweErim5o4RX91tQhBBKJT1DM1pzUlSSksm_eYrmMX5liNVleYGmvBRkWRE-Q_o9Hsw2dGHjjOpwGJMJPUTsPFbtXnkDLTZHGfBOJQc-RaxsyusABtze-Q3egA-9MziNfcjYEKzrjv4AcexSvETnVnURrk66QJ9Pjx-rl2L99vy6elgXailpKmyldQkgNK-WLVPSCmGpksC5XrJKMiFqW9KSZYNJYiyXuq6M1KLOvUQLbIFuf3PzBd8jxNT0LhroOuUhjLHJCZIxJjjN6M0JHXUPbbMbXK-GQ_P3F_YDI4hnFg |
| CitedBy_id | crossref_primary_10_1016_j_jstrokecerebrovasdis_2024_108215 crossref_primary_10_1111_bjhp_12773 crossref_primary_10_1136_bmjopen_2024_097620 crossref_primary_10_1136_bmjopen_2023_072472 |
| ContentType | Journal Article |
| CorporateAuthor | Members of the PiGeOn Project |
| CorporateAuthor_xml | – name: Members of the PiGeOn Project |
| DBID | NPM 7X8 |
| DOI | 10.1037/hea0001181 |
| DatabaseName | PubMed MEDLINE - Academic |
| DatabaseTitle | PubMed MEDLINE - Academic |
| DatabaseTitleList | PubMed MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database |
| DeliveryMethod | no_fulltext_linktorsrc |
| Discipline | Medicine Public Health Psychology |
| EISSN | 1930-7810 |
| ExternalDocumentID | 35604703 |
| Genre | Journal Article |
| GrantInformation_xml | – fundername: Cancer Institute NSW – fundername: National Health and Medical Research Council – fundername: Cancer Institute of NSW |
| GroupedDBID | --- --Z -DZ .GJ 0R~ 186 29I 354 53G 5GY 5RE 5VS 7RZ AAWTL ABIVO ABNCP ABVOZ ACGFO ACHQT ACPQG ADXHL AEHFB AENEX AETEA AI. ALMA_UNASSIGNED_HOLDINGS AWKKM AZXWR CGNQK CS3 D0L DU5 EPA F5P FD6 FTD HVGLF HZ~ H~9 ISO LW5 N4W NPM O9- OHT OPA OVD P2P PHGZM PHGZT ROL SES SPA TAE TEORI TN5 UHS UPT VH1 WH7 XJT YR2 YR5 ZCA ZGI ZHY ZPI ~G0 3KI 7X8 PUEGO |
| ID | FETCH-LOGICAL-a481t-f7bb5ee6b374d2a8f66f1a8e33b42782669f5152e33280cf38b97c8b690006de2 |
| IEDL.DBID | 7X8 |
| ISICitedReferencesCount | 5 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000798615300008&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 1930-7810 |
| IngestDate | Sat Sep 27 21:01:11 EDT 2025 Mon Jul 21 05:55:58 EDT 2025 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 6 |
| Language | English |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-a481t-f7bb5ee6b374d2a8f66f1a8e33b42782669f5152e33280cf38b97c8b690006de2 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| ORCID | 0000-0001-8512-0121 0000-0002-5086-0784 0000-0001-9665-8963 0000-0001-6142-3291 0000-0003-1570-8872 0000-0001-9396-4113 0000-0001-7746-9649 0000-0002-9706-0514 0000-0001-8009-7735 0000-0003-3562-6954 0000-0001-9052-1616 0000-0002-2527-5428 |
| OpenAccessLink | http://hdl.handle.net/1959.4/unsworks_85197 |
| PMID | 35604703 |
| PQID | 2668222631 |
| PQPubID | 23479 |
| ParticipantIDs | proquest_miscellaneous_2668222631 pubmed_primary_35604703 |
| PublicationCentury | 2000 |
| PublicationDate | 2022-06-01 |
| PublicationDateYYYYMMDD | 2022-06-01 |
| PublicationDate_xml | – month: 06 year: 2022 text: 2022-06-01 day: 01 |
| PublicationDecade | 2020 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States |
| PublicationTitle | Health psychology |
| PublicationTitleAlternate | Health Psychol |
| PublicationYear | 2022 |
| SSID | ssj0002955 |
| Score | 2.4051318 |
| Snippet | Comprehensive tumor genomic profiling (CGP) offers hope for personalized treatment for cancer patients when other treatment options have been exhausted.... |
| SourceID | proquest pubmed |
| SourceType | Aggregation Database Index Database |
| StartPage | 396 |
| Title | Psychological outcomes in advanced cancer patients after receiving genomic tumor profiling results |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/35604703 https://www.proquest.com/docview/2668222631 |
| Volume | 41 |
| WOSCitedRecordID | wos000798615300008&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1bS8MwFD6oExmIl3m_EcHXsjXpmvRJRBy-bOxBYW-lSRMYuHaureC_9yRtHT4Igi8thF7SJP3Ol5OT8wHc-UmC9Qu0ZyhOUYKhMl4S2BArhcZeyUgymjqxCT6ZiNksmjYOt6IJq2wx0QF1mivrI--jIbG2LGT-_fLds6pRdnW1kdDYhA5DKmNDuvhsnS2cRk71FDmKjZrzB216Usb7iHSODgn_d2rpTMxo_7-VO4C9hlySh3o0HMKGznqwM26Wz3vQ_Ya7zx7s1h47Um9EOgL5AwtJXpX4bl2QeUbaQAGi7GlFmmSsBXEK4wRBU8-tY4LYjK8LfGZZLXK8zOmB23Kc01dvZXEMr6Onl8dnr1FgwA4TfukZLuVQ61AyHqQ0ESYMjZ8IzZi0Eh342ZFBQkSxgIqBMkzIiCshQytFGqaansBWlmf6DEhCWaS5TCLjq4CrSEpu9-yGBvlmKFL_HG7bpo1xhNtliyTTeVXE68Y9h9O6f-JlnYojZkjYAgStiz_cfQldavcuOBfKFXQM_t_6GrbVRzkvVjdu6OBxMh1_ATfYz9U |
| linkProvider | ProQuest |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Psychological+outcomes+in+advanced+cancer+patients+after+receiving+genomic+tumor+profiling+results&rft.jtitle=Health+psychology&rft.au=Vatter%2C+Sabina&rft.au=Schlub%2C+Timothy+E&rft.au=Napier%2C+Christine+E&rft.au=Best%2C+Megan+C&rft.date=2022-06-01&rft.eissn=1930-7810&rft.volume=41&rft.issue=6&rft.spage=396&rft_id=info:doi/10.1037%2Fhea0001181&rft_id=info%3Apmid%2F35604703&rft_id=info%3Apmid%2F35604703&rft.externalDocID=35604703 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1930-7810&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1930-7810&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1930-7810&client=summon |