Effect of Alzheimer's disease risk genes on trajectories of cognitive function in the Cardiovascular Health Study

The trajectory of cognitive decline in patients with late-onset Alzheimer's disease varies widely. Genetic variations in CLU, PICALM, and CR1 are associated with Alzheimer's disease, but it is unknown whether they exert their effects by altering cognitive trajectory in elderly individuals...

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Vydané v:	The American journal of psychiatry Ročník 169; číslo 9; s. 954
Hlavní autori:	Sweet, Robert A, Seltman, Howard, Emanuel, James E, Lopez, Oscar L, Becker, James T, Bis, Joshua C, Weamer, Elise A, DeMichele-Sweet, Mary Ann A, Kuller, Lewis H
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 01.09.2012
Predmet:	Age of Onset Aged Alleles Alzheimer Disease - complications Alzheimer Disease - genetics Alzheimer Disease - psychology Apolipoprotein E4 - genetics Bayes Theorem Clusterin - genetics Cohort Studies Dementia - complications Dementia - genetics Dementia - psychology Disease Progression Female Genetic Predisposition to Disease - genetics Humans Male Models, Psychological Monomeric Clathrin Assembly Proteins - genetics Polymorphism, Single Nucleotide - genetics Receptors, Complement 3b - genetics Risk Factors
ISSN:	1535-7228, 1535-7228
On-line prístup:	Zistit podrobnosti o prístupe
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