Secretome Analysis of Lipid-Induced Insulin Resistance in Skeletal Muscle Cells by a Combined Experimental and Bioinformatics Workflow

Skeletal muscle has emerged as an important secretory organ that produces so-called myokines, regulating energy metabolism via autocrine, paracrine, and endocrine actions; however, the nature and extent of the muscle secretome has not been fully elucidated. Mass spectrometry (MS)-based proteomics, i...

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Bibliographic Details
Published in:	Journal of proteome research Vol. 14; no. 11; pp. 4885 - 4895
Main Authors:	Deshmukh, Atul S, Cox, Juergen, Jensen, Lars Juhl, Meissner, Felix, Mann, Matthias
Format:	Journal Article
Language:	English
Published:	United States American Chemical Society 06.11.2015
Subjects:	Amino Acid Sequence Animals Cell Differentiation Cell Line Computational Biology - methods Cytokines - genetics Cytokines - isolation & purification Cytokines - secretion Gene Expression Regulation Glucose - metabolism Glucose - pharmacology Insulin - metabolism Insulin - pharmacology Insulin Resistance Insulin-Like Growth Factor Binding Proteins - genetics Insulin-Like Growth Factor Binding Proteins - isolation & purification Insulin-Like Growth Factor Binding Proteins - secretion Intercellular Signaling Peptides and Proteins - genetics Intercellular Signaling Peptides and Proteins - isolation & purification Intercellular Signaling Peptides and Proteins - secretion Metalloproteases - genetics Metalloproteases - isolation & purification Metalloproteases - secretion Mice Molecular Sequence Data Muscle Fibers, Skeletal - cytology Muscle Fibers, Skeletal - drug effects Muscle Fibers, Skeletal - secretion Myoblasts - cytology Myoblasts - drug effects Myoblasts - secretion Palmitic Acid - pharmacology Protein Sorting Signals - genetics Protein Structure, Tertiary Serum Albumin, Bovine - chemistry insulin signaling glucose uptake mass spectrometry myokines metabolism secretome diabetes palmitic acid quantitative proteomics obesity
ISSN:	1535-3893, 1535-3907, 1535-3907
Online Access:	Get full text
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