Identification of Two Secondary Ligand Binding Sites in 14-3-3 Proteins Using Fragment Screening

Proteins typically interact with multiple binding partners, and often different parts of their surfaces are employed to establish these protein-protein interactions (PPIs). Members of the class of 14-3-3 adapter proteins bind to several hundred other proteins in the cell. Multiple small molecules fo...

Full description

Saved in:

Bibliographic Details
Published in:	Biochemistry (Easton) Vol. 56; no. 30; p. 3972
Main Authors:	Sijbesma, Eline, Skora, Lukasz, Leysen, Seppe, Brunsveld, Luc, Koch, Uwe, Nussbaumer, Peter, Jahnke, Wolfgang, Ottmann, Christian
Format:	Journal Article
Language:	English
Published:	United States 01.08.2017
Subjects:	14-3-3 Proteins - chemistry 14-3-3 Proteins - genetics 14-3-3 Proteins - metabolism Amino Acid Sequence Binding Sites Biomarkers, Tumor - chemistry Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Conserved Sequence Crystallography, X-Ray Exoribonucleases - chemistry Exoribonucleases - genetics Exoribonucleases - metabolism Gene Deletion Humans Kinetics Ligands Models, Molecular Nuclear Magnetic Resonance, Biomolecular Peptide Fragments - chemistry Peptide Fragments - genetics Peptide Fragments - metabolism Peptide Library Phosphorylation Protein Conformation Protein Interaction Domains and Motifs Protein Interaction Mapping Protein Isoforms - chemistry Protein Isoforms - genetics Protein Isoforms - metabolism Protein Processing, Post-Translational Recombinant Fusion Proteins - chemistry Recombinant Fusion Proteins - metabolism Recombinant Proteins - chemistry Recombinant Proteins - metabolism Transcription Factors - chemistry Transcription Factors - genetics Transcription Factors - metabolism
ISSN:	1520-4995, 1520-4995
Online Access:	Get more information
Tags:	Add Tag No Tags, Be the first to tag this record!

Be the first to leave a comment!