Synthesis and Potent Antimalarial Activity of Kalihinol B

Of the 50+ kalihinane diterpenoids reported to date, only five had been tested for antimalarial activity, in spite of the fact that kalihinol A is the most potent among the members of the larger family of antimalarial isocyanoterpenes. We have validated a strategy designed to access many of the kali...

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Bibliographic Details
Published in:	Journal of the American Chemical Society Vol. 137; no. 15; pp. 4912 - 4915
Main Authors:	Daub, Mary Elisabeth, Prudhomme, Jacques, Le Roch, Karine, Vanderwal, Christopher D
Format:	Journal Article
Language:	English
Published:	WASHINGTON American Chemical Society 22.04.2015 Amer Chemical Soc
Subjects:	Antimalarials - chemical synthesis Antimalarials - chemistry Antimalarials - pharmacology Chemistry Chemistry, Multidisciplinary Chloroquine - pharmacology Diterpenes - chemical synthesis Diterpenes - chemistry Diterpenes - pharmacology Drug Resistance - drug effects Molecular Structure Parasitic Sensitivity Tests Physical Sciences Plasmodium falciparum - drug effects Science & Technology SPONGE ETHER NATURAL-PRODUCTS DITERPENE ISONITRILES RESISTANCE ALDEHYDES TERPENOIDS MICHAEL ADDITION
ISSN:	0002-7863, 1520-5126, 1520-5126
Online Access:	Get full text
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