In vitro activities of novel antifolate drug combinations against Plasmodium falciparum and human granulocyte CFUs

The potency of antimalarial dihydrofolate reductase inhibitors, alone and in synergistic combination with dihydropteroate synthetase inhibitors, against the Kenyan K39 strain of Plasmodium falciparum (pyrimethamine resistant) and against normal replicating human bone marrow cells in in vitro culture...

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Bibliographic Details

Published in:	Antimicrobial agents and chemotherapy Vol. 39; no. 4; p. 948
Main Authors:	Winstanley, P A, Mberu, E K, Szwandt, I S, Breckenridge, A M, Watkins, W M
Format:	Journal Article
Language:	English
Published:	United States 01.04.1995
Subjects:	Animals Dapsone - pharmacology Dihydropteroate Synthase - antagonists & inhibitors Drug Combinations Drug Synergism Folic Acid Antagonists - pharmacology Granulocytes - drug effects Hematopoietic Stem Cells - drug effects Humans Plasmodium falciparum - drug effects Proguanil - analogs & derivatives Proguanil - pharmacology
ISSN:	0066-4804
Online Access:	Get more information
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