The genetics of narcolepsy

Human narcolepsy is a genetically complex disorder. Family studies indicate a 20-40 times increased risk of narcolepsy in first-degree relatives and twin studies suggest that nongenetic factors also play a role. The tight association between narcolepsy-cataplexy and the HLA allele DQB1*0602 suggests...

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Veröffentlicht in:	Annual review of genomics and human genetics Jg. 4; S. 459
Hauptverfasser:	Chabas, Dorothee, Taheri, Shahrad, Renier, Corinne, Mignot, Emmanuel
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 01.01.2003
Schlagworte:	Animals Autoimmunity Carrier Proteins - genetics Disease Models, Animal Dogs Genetic Predisposition to Disease HLA-DQ Antigens - genetics HLA-DQ beta-Chains Humans Intracellular Signaling Peptides and Proteins Mice Narcolepsy - genetics Neuropeptides - genetics Orexins
ISSN:	1527-8204
Online-Zugang:	Weitere Angaben
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