CRISPR/Cas9-Based Genome Editing for Disease Modeling and Therapy: Challenges and Opportunities for Nonviral Delivery

Genome editing offers promising solutions to genetic disorders by editing DNA sequences or modulating gene expression. The clustered regularly interspaced short palindromic repeats (CRISPR)/associated protein 9 (CRISPR/Cas9) technology can be used to edit single or multiple genes in a wide variety o...

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Bibliographic Details

Published in:	Chemical reviews Vol. 117; no. 15; p. 9874
Main Authors:	Wang, Hong-Xia, Li, Mingqiang, Lee, Ciaran M, Chakraborty, Syandan, Kim, Hae-Won, Bao, Gang, Leong, Kam W
Format:	Journal Article
Language:	English
Published:	United States 09.08.2017
Subjects:	CRISPR-Cas Systems - genetics Gene Editing Gene Transfer Techniques Genetic Therapy - methods Humans Models, Biological
ISSN:	1520-6890, 1520-6890
Online Access:	Get more information
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