Enhanced sensitivity for high spatial resolution lipid analysis by negative ion mode matrix assisted laser desorption ionization imaging mass spectrometry

We have achieved enhanced lipid imaging to a ~10 μm spatial resolution using negative ion mode matrix assisted laser desorption ionization (MALDI) imaging mass spectrometry, sublimation of 2,5-dihydroxybenzoic acid as the MALDI matrix, and a sample preparation protocol that uses aqueous washes. We r...

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Vydané v:	Analytical chemistry (Washington) Ročník 84; číslo 3; s. 1557
Hlavní autori:	Angel, Peggi M, Spraggins, Jeffrey M, Baldwin, H Scott, Caprioli, Richard
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 07.02.2012
Predmet:	Acetates - chemistry Animals Brain - metabolism Formates - chemistry Hydrogen-Ion Concentration Ions - chemistry Lipids - analysis Mice Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
ISSN:	1520-6882, 1520-6882
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