Enhanced sensitivity for high spatial resolution lipid analysis by negative ion mode matrix assisted laser desorption ionization imaging mass spectrometry

We have achieved enhanced lipid imaging to a ~10 μm spatial resolution using negative ion mode matrix assisted laser desorption ionization (MALDI) imaging mass spectrometry, sublimation of 2,5-dihydroxybenzoic acid as the MALDI matrix, and a sample preparation protocol that uses aqueous washes. We r...

Full description

Bibliographic Details

Published in:	Analytical chemistry (Washington) Vol. 84; no. 3; p. 1557
Main Authors:	Angel, Peggi M, Spraggins, Jeffrey M, Baldwin, H Scott, Caprioli, Richard
Format:	Journal Article
Language:	English
Published:	United States 07.02.2012
Subjects:	Acetates - chemistry Animals Brain - metabolism Formates - chemistry Hydrogen-Ion Concentration Ions - chemistry Lipids - analysis Mice Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
ISSN:	1520-6882, 1520-6882
Online Access:	Get more information
Tags:	Add Tag No Tags, Be the first to tag this record!