Molecular characterization and resistance mechanisms of ertapenem-non-susceptible carbapenem-resistant Klebsiella pneumoniae co-harboring ESBLs or AmpC enzymes with porin loss or efflux pump overexpression

This study highlights the complex, multifactorial nature of carbapenem resistance in carbapenem-resistant Klebsiella pneumoniae (CRKP), involving enzyme-mediated resistance, reduced membrane porin expression, and overactive efflux pumps. These findings provide valuable insights into CRKP resistance...

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Bibliographic Details
Published in:	Journal of bacteriology Vol. 207; no. 7; p. e0014825
Main Authors:	Su, Yingying, Zou, Guangmei, Huang, Xin, Bi, Jinli, Meng, Liqin, Zhao, Wei, Li, Taijie
Format:	Journal Article
Language:	English
Published:	United States American Society for Microbiology 24.07.2025
Subjects:	Anti-Bacterial Agents - pharmacology Bacterial Proteins - genetics Bacterial Proteins - metabolism Bacteriology beta-Lactamases - genetics beta-Lactamases - metabolism carbapenem-resistant Klebsiella pneumonia Carbapenemase Carbapenems Carbapenems - pharmacology Clinical isolates Drug Resistance, Multiple, Bacterial Efflux efflux pump Ertapenem Ertapenem - pharmacology Gene Expression Regulation, Bacterial Gene sequencing Genes Humans Klebsiella Klebsiella Infections - microbiology Klebsiella pneumoniae Klebsiella pneumoniae - drug effects Klebsiella pneumoniae - enzymology Klebsiella pneumoniae - genetics Klebsiella pneumoniae - metabolism mechanisms of drug resistance Microbial Sensitivity Tests Multidrug resistance N-Acetylmuramoyl-L-alanine Amidase - genetics N-Acetylmuramoyl-L-alanine Amidase - metabolism outer membrane porin Porins - genetics Porins - metabolism Proteins Research Article β Lactamase efflux pump carbapenemase carbapenem-resistant Klebsiella pneumonia mechanisms of drug resistance outer membrane porin
ISSN:	0021-9193, 1098-5530, 1098-5530
Online Access:	Get full text
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