Molecular characterization and resistance mechanisms of ertapenem-non-susceptible carbapenem-resistant Klebsiella pneumoniae co-harboring ESBLs or AmpC enzymes with porin loss or efflux pump overexpression

This study highlights the complex, multifactorial nature of carbapenem resistance in carbapenem-resistant Klebsiella pneumoniae (CRKP), involving enzyme-mediated resistance, reduced membrane porin expression, and overactive efflux pumps. These findings provide valuable insights into CRKP resistance...

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Bibliographic Details
Published in:Journal of bacteriology Vol. 207; no. 7; p. e0014825
Main Authors: Su, Yingying, Zou, Guangmei, Huang, Xin, Bi, Jinli, Meng, Liqin, Zhao, Wei, Li, Taijie
Format: Journal Article
Language:English
Published: United States American Society for Microbiology 24.07.2025
Subjects:
Anti-Bacterial Agents - pharmacology
Bacterial Proteins - genetics
Bacterial Proteins - metabolism
Bacteriology
beta-Lactamases - genetics
beta-Lactamases - metabolism
carbapenem-resistant Klebsiella pneumonia
Carbapenemase
Carbapenems
Carbapenems - pharmacology
Clinical isolates
Drug Resistance, Multiple, Bacterial
Efflux
efflux pump
Ertapenem
Ertapenem - pharmacology
Gene Expression Regulation, Bacterial
Gene sequencing
Genes
Humans
Klebsiella
Klebsiella Infections - microbiology
Klebsiella pneumoniae
Klebsiella pneumoniae - drug effects
Klebsiella pneumoniae - enzymology
Klebsiella pneumoniae - genetics
Klebsiella pneumoniae - metabolism
mechanisms of drug resistance
Microbial Sensitivity Tests
Multidrug resistance
N-Acetylmuramoyl-L-alanine Amidase - genetics
N-Acetylmuramoyl-L-alanine Amidase - metabolism
outer membrane porin
Porins - genetics
Porins - metabolism
Proteins
Research Article
β Lactamase
efflux pump
carbapenemase
carbapenem-resistant Klebsiella pneumonia
mechanisms of drug resistance
outer membrane porin
ISSN:0021-9193, 1098-5530, 1098-5530
Online Access:Get full text
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Summary:This study highlights the complex, multifactorial nature of carbapenem resistance in carbapenem-resistant Klebsiella pneumoniae (CRKP), involving enzyme-mediated resistance, reduced membrane porin expression, and overactive efflux pumps. These findings provide valuable insights into CRKP resistance mechanisms and can aid in controlling CRKP in China.
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Yingying Su and Guangmei Zou contributed equally to this article. Author order was determined by drawing straws.
The authors declare no conflict of interest.
ISSN:0021-9193
1098-5530
1098-5530
DOI:10.1128/jb.00148-25