Alpinia zerumbet potentially elevates high-density lipoprotein cholesterol level in hamsters

In folkloric plant medicines, Alpinia zerumbet (AZ) has been popularly recognized as an exellent hepatoprotector. To search for a good high-density lipoprotein cholesterol (HDL-C) elevating herbal preparation, we examined AZ for its antioxidant and hypolipidaemic bioactivities, especially its HDL-C...

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Vydané v:Journal of agricultural and food chemistry Ročník 56; číslo 12; s. 4435
Hlavní autori: Lin, Li-Yun, Peng, Chiung-Chi, Liang, Yu-Jing, Yeh, Wan-Ting, Wang, Hui-Er, Yu, Tung-Hsi, Peng, Robert Y
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: United States 25.06.2008
Predmet:
Alpinia - chemistry
Animals
Cholesterol, HDL - blood
Cholesterol, LDL - blood
Cricetinae
Flavonoids - analysis
Lipid Peroxidation - drug effects
Liver - anatomy & histology
Male
Mesocricetus
Oils, Volatile - analysis
Organ Size - drug effects
Phenols - analysis
Plant Extracts - pharmacology
Polyphenols
Quercetin - analysis
Rutin - analysis
Terpenes - analysis
ISSN:1520-5118, 1520-5118
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Shrnutí:In folkloric plant medicines, Alpinia zerumbet (AZ) has been popularly recognized as an exellent hepatoprotector. To search for a good high-density lipoprotein cholesterol (HDL-C) elevating herbal preparation, we examined AZ for its antioxidant and hypolipidaemic bioactivities, especially its HDL-C elevating activity. AZ seeds contain 0.51% essential oils (SO), which are comprised of monoterpenoids, oxygenated monoterpenoids, sesquiterpenoids, oxygenated sesquiterpenoids, aldehydes, acid, and esters. Gas chromatography/mass spectrometry analysis indicated that most of the monoterpenes and sesquiterpenes were recoverable in pentane eluent, whilst the oxygenated monoterpenoids and sesquiterpenoids remained in ether eluent. The high contents of rutin, quercetin, and polyphenolics in ethanolic extract of AZ seeds exhibit moderate antilipoperoxidative but potent DPPH free radical scavenging bioactivities. Conclusively, both seed powder (SP) and SO are effective hypolipidaemics with amazingly potent HDL-C elevating capabilities. On the basis of hepatoprotectivity, SP is a more feasible hypolipidemic agent as well as a promising HDL-C elevating plant medicine.
Bibliografia:ObjectType-Article-1
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ISSN:1520-5118
1520-5118
DOI:10.1021/jf800195d