d-Glucuronate and d-Glucuronate Glycal Acceptors for the Scalable Synthesis of d-GlcN-α-1,4-d-GlcA Disaccharides and Modular Assembly of Heparan Sulfate

Reported herein is a scalable chemical synthesis of disaccharidebuilding blocks for heparan sulfate (HS) oligosaccharide assembly.The use of d-glucuronate-based acceptors for dehydrativeglycosylation with d-glucosamine partners is explored, enablingdiastereoselective synthesis of appropriately prote...

Full description

Bibliographic Details

Published in:	Journal of organic chemistry Vol. 88; no. 15; pp. 11130 - 11139
Main Authors:	Pongener, Imlirenla, Miller, Gavin J. J.
Format:	Journal Article
Language:	English
Published:	WASHINGTON Amer Chemical Soc 04.08.2023
Subjects:	Chemistry Chemistry, Organic Physical Sciences Science & Technology HERPES-SIMPLEX-VIRUS ACTIVATION ACID OLIGOSACCHARIDES MOIETY STRATEGY DODECASACCHARIDES GLYCOSYL PHOSPHATES CHEMICAL-SYNTHESIS BINDING
ISSN:	0022-3263, 1520-6904, 1520-6904
Online Access:	Get more information
Tags:	Add Tag No Tags, Be the first to tag this record!