Deciphering the Coevolutionary Dynamics of L2 β-Lactamases via Deep Learning

L2 β-lactamases, serine-based class A β-lactamases expressed by , play a pivotal role in antimicrobial resistance (AMR). However, limited studies have been conducted on these important enzymes. To understand the coevolutionary dynamics of L2 β-lactamase, innovative computational methodologies, inclu...

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Bibliographic Details

Published in:	Journal of chemical information and modeling Vol. 64; no. 9; p. 3706
Main Authors:	Zhu, Yu, Gu, Jing, Zhao, Zhuoran, Chan, A W Edith, Mojica, Maria F, Hujer, Andrea M, Bonomo, Robert A, Haider, Shozeb
Format:	Journal Article
Language:	English
Published:	United States 13.05.2024
Subjects:	beta-Lactamases - chemistry beta-Lactamases - metabolism Deep Learning Evolution, Molecular Molecular Dynamics Simulation Protein Conformation Stenotrophomonas maltophilia - enzymology
ISSN:	1549-960X, 1549-960X
Online Access:	Get more information
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