Music exposure enhances resistance to Salmonella infection by promoting healthy gut microbiota

Music therapy is increasingly recognized as a low-cost approach to improving health, but how it works remains unclear. Our study demonstrates that music can positively influence health by altering the gut microbiome. In a mouse model, exposure to Mozart’s Flute Quartet in D Major enhanced the gut mi...

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Veröffentlicht in:Microbiology spectrum Jg. 13; H. 5; S. e0237724
Hauptverfasser: Zhu, Clara Y., Byun, Hyuntae, Do, Elyza A., Zhang, Yue, Tanchoco, Ethan, Beld, Joris, Hsiao, Ansel, Zhu, Jun
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States American Society for Microbiology 25.03.2025
Schlagworte:
Bacteriology
Lactobacillus
metabolomics
microbiota
music therapy
Research Article
Salmonella
microbiota
Salmonella
music therapy
metabolomics
Lactobacillus
ISSN:2165-0497, 2165-0497
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Zusammenfassung:Music therapy is increasingly recognized as a low-cost approach to improving health, but how it works remains unclear. Our study demonstrates that music can positively influence health by altering the gut microbiome. In a mouse model, exposure to Mozart’s Flute Quartet in D Major enhanced the gut microbiota, specifically increasing levels of the beneficial bacterium Lactobacillus salivarius . This probiotic protected mice from Salmonella infection by creating an acidic environment that inhibited pathogen growth. Mozart-treated mice also showed reduced anxiety, better spatial memory, and higher food intake without weight gain, suggesting the benefits of music exposure. These findings reveal a novel link between music, gut health, and disease resistance, suggesting that music therapy could be a promising strategy for enhancing gut microbiota and combating infections, including those caused by drug-resistant bacteria.
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Present address: School of Medicine, Oregon Health and Science University, Portland, Oregon, USA
The authors declare no conflict of interest.
Clara Y. Zhu and Hyuntae Byun contributed equally to this article. Author order was determined based on their primary roles in the project, with the experimental lead listed first.
ISSN:2165-0497
2165-0497
DOI:10.1128/spectrum.02377-24