Molecular epidemiology and clinical features of Klebsiella variicola bloodstream infection compared with infection with other Klebsiella pneumoniae species complex strains

Klebsiella variicola is increasingly recognized as an emerging pathogen commonly found in the environment and human gut. However, its clinical and microbiological characteristics remain poorly understood. This study provides a comprehensive analysis of K. variicola bloodstream infections (BSIs), com...

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Vydáno v:	Microbiology spectrum Ročník 13; číslo 6; s. e0301724
Hlavní autoři:	Ohno, Tatsuya, Harada, Sohei, Saito, Hiroki, Tanii, Rimi, Komori, Kohji, Kurosawa, Miki, Wakatake, Haruaki, Kanazawa, Minoru, Ohki, Uiri, Minoura, Ayu, Yamada, Mario, Kaneko, Satsuki, Anzai, Momoko, Tsutsui, Yuto, Kuhara, Asuka, Oyanagi, Tadatomo, Tanaka, Yosuke, Takemura, Hiromu, Takeuchi, Hiroaki, Kunishima, Hiroyuki
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States American Society for Microbiology 03.06.2025
Témata:	Adult Aged Aged, 80 and over Bacteremia - epidemiology Bacteremia - microbiology bloodstream infections Case-Control Studies Clinical Microbiology Female Humans hypervirulent Japan - epidemiology Klebsiella - classification Klebsiella - genetics Klebsiella - isolation & purification Klebsiella - pathogenicity Klebsiella Infections - epidemiology Klebsiella Infections - microbiology Klebsiella Infections - mortality Klebsiella Infections - pathology Klebsiella pneumoniae Klebsiella pneumoniae - classification Klebsiella pneumoniae - genetics Klebsiella pneumoniae - isolation & purification Klebsiella pneumoniae - pathogenicity Klebsiella variicola Liver Abscess - microbiology Male Middle Aged Molecular Epidemiology Multilocus Sequence Typing Research Article Retrospective Studies Virulence - genetics Virulence Factors - genetics Whole Genome Sequencing Japan bloodstream infections molecular epidemiology Klebsiella variicola hypervirulent Klebsiella pneumoniae
ISSN:	2165-0497, 2165-0497
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Shrnutí:	Klebsiella variicola is increasingly recognized as an emerging pathogen commonly found in the environment and human gut. However, its clinical and microbiological characteristics remain poorly understood. This study provides a comprehensive analysis of K. variicola bloodstream infections (BSIs), comparing clinical and genetic features with the closely related K. pneumoniae . We identified significant differences in the prevalence of virulence genes between the two species. Notably, we observed K. variicola causing disseminated liver abscesses, similar to hypervirulent K. pneumoniae strains. These findings have important implications for accurate species identification, informing treatment strategies, and improving patient outcomes in the face of this emerging infectious threat.
Bibliografie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 S.H. reports receiving speaker payments from MSD, Shionogi, and Pfizer, and consulting fees from Shionogi, Pfizer, and Denka outside the submitted work. The other authors declare no conflict of interest.
ISSN:	2165-0497 2165-0497
DOI:	10.1128/spectrum.03017-24