Bioaccessibility of Organic Compounds Associated with Tire Particles Using a Fish In Vitro Digestive Model: Solubilization Kinetics and Effects of Food Coingestion

Tire and road wear particles (TRWP) account for an important part of the polymer particles released into the environment. There are scientific knowledge gaps as to the potential bioaccessibility of chemicals associated with TRWP to aquatic organisms. This study investigated the solubilization and bi...

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Bibliographic Details
Published in:Environmental science & technology Vol. 56; no. 22; p. 15607
Main Authors: Masset, Thibault, Ferrari, Benoit J D, Dudefoi, William, Schirmer, Kristin, Bergmann, Alan, Vermeirssen, Etienne, Grandjean, Dominique, Harris, Luke Christopher, Breider, Florian
Format: Journal Article
Language:English
Published: United States 15.11.2022
Subjects:
Amphipoda
Animals
Benzoquinones - metabolism
Benzoquinones - toxicity
Digestion
Gastric Juice - metabolism
In Vitro Techniques
Intestinal Mucosa - drug effects
Intestinal Mucosa - metabolism
Intestinal Secretions - metabolism
Kinetics
Oncorhynchus mykiss - metabolism
Organic Chemicals - metabolism
Organic Chemicals - toxicity
Phenylenediamines - metabolism
Phenylenediamines - toxicity
Rubber - metabolism
Rubber - toxicity
TRWP
digestive fluids
additives
microplastics
tire
tyre
chemical leaching 6PPD(Q)
ISSN:1520-5851, 1520-5851
Online Access:Get more information
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Summary:Tire and road wear particles (TRWP) account for an important part of the polymer particles released into the environment. There are scientific knowledge gaps as to the potential bioaccessibility of chemicals associated with TRWP to aquatic organisms. This study investigated the solubilization and bioaccessibility of seven of the most widely used tire-associated organic chemicals and four of their degradation products from cryogenically milled tire tread (CMTT) into fish digestive fluids using an digestion model based on . Our results showed that 0.06-44.1% of the selected compounds were rapidly solubilized into simulated gastric and intestinal fluids within a typical gut transit time for fish (3 h in gastric and 24 h in intestinal fluids). The environmentally realistic scenario of coingestion of CMTT and fish prey was explored using ground . Coingestion caused compound-specific changes in solubilization, either increasing or decreasing the compounds' bioaccessibility in simulated gut fluids compared to CMTT alone. Our results emphasize that tire-associated compounds become accessible in a digestive milieu and should be studied further with respect to their bioaccumulation and toxicological effects upon passage of intestinal epithelial cells.
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ISSN:1520-5851
1520-5851
DOI:10.1021/acs.est.2c04291