Characterization and Quantification of Oxidized High Mobility Group Box 1 Proteoforms Secreted from Hepatocytes by Toxic Levels of Acetaminophen

The high mobility group box 1 (HMGB1), which is released during acute acetaminophen (APAP) overdose, is thought to mediate a subsequent immune response, particularly hepatic infiltration of macrophages. The redox behavior of HMGB1 and the proteoforms of HMGB1 present in oxidative environments has be...

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Bibliographic Details

Published in:	Chemical research in toxicology Vol. 35; no. 10; p. 1893
Main Authors:	Pirnie, Ross, Gillespie, Kevin P, Weng, Liwei, Mesaros, Clementina, Blair, Ian A
Format:	Journal Article
Language:	English
Published:	United States 17.10.2022
Subjects:	Acetaminophen - toxicity Biomarkers - metabolism Cysteic Acid - metabolism Cysteine - chemistry Disulfides - chemistry Hepatocytes - metabolism HMGB1 Protein - metabolism Oxidation-Reduction Peptides - metabolism Proteins - metabolism Sulfhydryl Compounds - metabolism
ISSN:	1520-5010, 1520-5010
Online Access:	Get more information
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