Stereoisomers of an Aryl Pyrazole Glucocorticoid Receptor Agonist Scaffold Elicit Differing Anti-inflammatory Responses

Glucocorticoids (GCs) are heavily prescribed to control inflammation in various human diseases; however, side effects associated with GCs are well documented and lead to serious metabolic and immunological complications with long-term use. The paradigm for GC function includes two well described mod...

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Vydané v:	ACS medicinal chemistry letters Ročník 13; číslo 9; s. 1493 - 1499
Hlavní autori:	Lato, Ashley M., Burke, Susan J., Ducote, Maggie P., Kennedy, Brandon J., Collier, J. Jason, Campagna, Shawn R.
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	WASHINGTON Amer Chemical Soc 08.09.2022
Predmet:	Chemistry, Medicinal Life Sciences & Biomedicine Pharmacology & Pharmacy Science & Technology Stereoisomers Aryl pyrazole DNA-BINDING MECHANISM LIGANDS STEREOCHEMISTRY Anti-inflammatory Glucocorticoid Molecular docking
ISSN:	1948-5875, 1948-5875
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