Ambiviricota , a novel ribovirian phylum for viruses with viroid-like properties

Fungi harbor a vast diversity of mobile genetic elements (MGEs). Recently, novel fungal MGEs, tentatively referred to as 'ambiviruses,' were described. 'Ambiviruses' have single-stranded RNA genomes of about 4-5 kb in length that contain at least two open reading frames (ORFs) in...

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Veröffentlicht in:Journal of virology Jg. 98; H. 7; S. e0083124
Hauptverfasser: Kuhn, Jens H, Botella, Leticia, de la Peña, Marcos, Vainio, Eeva J, Krupovic, Mart, Lee, Benjamin D, Navarro, Beatriz, Sabanadzovic, Sead, Simmonds, Peter, Turina, Massimo
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States 23.07.2024
Schlagworte:
Fungal Viruses - classification
Fungal Viruses - genetics
Fungal Viruses - isolation & purification
Fungi - genetics
Fungi - virology
Genome, Viral
Open Reading Frames
Phylogeny
RNA Viruses - classification
RNA Viruses - genetics
RNA, Viral - genetics
RNA-Dependent RNA Polymerase - genetics
Viroids - classification
Viroids - genetics
Ascomycota
ambivirus
International Committee on Taxonomy of Viruses
virus taxonomy
Basidiomycota
Riboviria
phylum
viroid
fungus
ambiviricot
fungi
twister
virus nomenclature
Ambiviricota
hairpin
hammerhead
virus classification
deltavirus
ICTV
ribozyme
ISSN:1098-5514, 1098-5514
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Beschreibung
Zusammenfassung:Fungi harbor a vast diversity of mobile genetic elements (MGEs). Recently, novel fungal MGEs, tentatively referred to as 'ambiviruses,' were described. 'Ambiviruses' have single-stranded RNA genomes of about 4-5 kb in length that contain at least two open reading frames (ORFs) in non-overlapping ambisense orientation. Both ORFs are conserved among all currently known 'ambiviruses,' and one of them encodes a distinct viral RNA-directed RNA polymerase (RdRP), the hallmark gene of ribovirian kingdom . However, 'ambivirus' genomes are circular and predicted to replicate via a rolling-circle mechanism. Their genomes are also predicted to form rod-like structures and contain ribozymes in various combinations in both sense and antisense orientations-features reminiscent of viroids, virusoids, ribozyvirian kolmiovirids, and yet-unclassified MGEs (such as 'epsilonviruses,' 'zetaviruses,' and some 'obelisks'). As a first step toward the formal classification of 'ambiviruses,' the International Committee on Taxonomy of Viruses (ICTV) recently approved the establishment of a novel ribovirian phylum, , to accommodate an initial set of 20 members with well-annotated genome sequences.
Bibliographie:ObjectType-Article-1
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content type line 23
ISSN:1098-5514
1098-5514
DOI:10.1128/jvi.00831-24