Detection of Pyrazinamide Heteroresistance in Mycobacterium tuberculosis

Heteroresistance is defined as the coexistence of both susceptible and resistant bacteria in a bacterial population. Previously published data show that it may occur in 9 to 57% of Mycobacterium tuberculosis isolates for various drugs. Pyrazinamide (PZA) is an important first-line drug used for trea...

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Bibliographic Details
Published in:	Antimicrobial agents and chemotherapy Vol. 65; no. 9; p. e0072021
Main Authors:	Werngren, Jim, Mansjö, Mikael, Glader, Mikaela, Hoffner, Sven, Davies Forsman, Lina
Format:	Journal Article
Language:	English
Published:	United States 17.08.2021
Subjects:	Amidohydrolases - genetics Antitubercular Agents - pharmacology Antitubercular Agents - therapeutic use Drug Resistance, Bacterial - genetics Humans Microbial Sensitivity Tests Mutation Mycobacterium tuberculosis - genetics Pyrazinamide - pharmacology Tuberculosis, Multidrug-Resistant - drug therapy Mycobacterium tuberculosis heteroresistance Wayne's test whole-genome sequencing method evaluation pyrazinamide drug susceptibility testing BACTEC MGIT 960
ISSN:	1098-6596, 1098-6596
Online Access:	Get more information
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