NMR Spectroscopy in Pharmaceutical Analysis

For almost a decade, quantitative NMR spectroscopy (qNMR) has been established as a valuable tool in drug analysis. In all disciplines, such as drug identification, impurity profiling and assay, qNMR can be utilized. Separation techniques such as high performance liquid chromatography, gas chromatog...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Holzgrabe, U. (Ulrike), Wawer, I. (Iwona), Diehl, B. (Bernd)
Format: E-Book Buch
Sprache:Englisch
Veröffentlicht: Oxford Elsevier 2008
Elsevier Science & Technology
Elsevier Science
Ausgabe:1
Schlagworte:
Drugs
Drugs > Analysis
Nuclear magnetic resonance spectroscopy
Pharmaceuticals
Pharmaceuticals, Cosmetics & Toiletries
ISBN:9780444531735, 0444531734
Online-Zugang:Volltext
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Beschreibung
Zusammenfassung:For almost a decade, quantitative NMR spectroscopy (qNMR) has been established as a valuable tool in drug analysis. In all disciplines, such as drug identification, impurity profiling and assay, qNMR can be utilized. Separation techniques such as high performance liquid chromatography, gas chromatography, super fluid chromatography and capillary electrophoresis techniques, govern the purity evaluation of drugs. However, these techniques are not always able to solve the analytical problems often resulting from insufficient methods. Nevertheless, such methods find their way into international pharmacopoeias. Thus, the aim of this book is to describe the possibilities of qNMR in pharmaceutical analysis. Besides the introduction to the physical fundamentals and techniques, the principles of the application in drug analysis are described: Quality evaluation of drugs, Polymer characterization, Natural products and corresponding reference compounds, Metabolism, and Solid phase NMR spectroscopy for the characterization drug substances, e.g. the water content, polymorphism, and drug formulations, e.g. tablets, powders. This part is accompanied by more special chapters dealing with representative examples that give more detailed information by means of concrete examples.
Bibliographie:Includes bibliographical references and index
ISBN:9780444531735
0444531734
DOI:10.1016/B978-0-444-53173-5.X0001-7