Optimized Loading Dose Strategies for Bedaquiline When Restarting Interrupted Drug-Resistant Tuberculosis Treatment

Interruption of treatment is common in drug-resistant tuberculosis patients. Bedaquiline has a long terminal half-life; therefore, restarting after an interruption without a loading dose could increase the risk of suboptimal treatment outcome and resistance development. We aimed to identify the most...

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Veröffentlicht in:	Antimicrobial agents and chemotherapy Jg. 66; H. 3; S. e0174921
Hauptverfasser:	Koele, Simon E, van Beek, Stijn W, Maartens, Gary, Brust, James C M, Svensson, Elin M
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 15.03.2022
Schlagworte:	Antitubercular Agents - pharmacokinetics Antitubercular Agents - therapeutic use Diarylquinolines - pharmacokinetics Diarylquinolines - therapeutic use Humans Long QT Syndrome - drug therapy Tuberculosis, Multidrug-Resistant - drug therapy Mycobacterium tuberculosis pharmacokinetics bedaquiline
ISSN:	1098-6596, 1098-6596
Online-Zugang:	Weitere Angaben
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