Polymersomes as Stable Nanocarriers for a Highly Immunogenic and Durable SARS-CoV‑2 Spike Protein Subunit Vaccine

Multiple successful vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are urgently needed to address the ongoing coronavirus disease 2019 (Covid-19) pandemic. In the present work, we describe a subunit vaccine based on the SARS-CoV-2 spike protein coadministered with CpG...

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Bibliographic Details
Published in:	ACS nano Vol. 15; no. 10; pp. 15754 - 15770
Main Authors:	Lam, Jian Hang, Khan, Amit K, Cornell, Thomas A, Chia, Teck Wan, Dress, Regine J, Yeow, Wen Wang William, Mohd-Ismail, Nur Khairiah, Venkataraman, Shrinivas, Ng, Kim Tien, Tan, Yee-Joo, Anderson, Danielle E, Ginhoux, Florent, Nallani, Madhavan
Format:	Journal Article
Language:	English
Published:	United States American Chemical Society 26.10.2021
Subjects:	Animals Antibodies, Neutralizing Antibodies, Viral CD8-Positive T-Lymphocytes COVID-19 - prevention & control COVID-19 Vaccines - immunology Humans Mice Mice, Inbred C57BL Nanoparticles Protein Subunits SARS-CoV-2 Spike Glycoprotein, Coronavirus - immunology Vaccines, Subunit neutralizing antibody polymersome vaccine ACM Covid-19 spike
ISSN:	1936-0851, 1936-086X, 1936-086X
Online Access:	Get full text
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