Molecular mechanisms controlling phosphate-induced downregulation of the yeast Pho84 phosphate transporter

In Saccharomyces cerevisiae, phosphate uptake is mainly dependent on the proton-coupled Pho84 permease under phosphate-limited growth conditions. Phosphate addition causes Pho84-mediated activation of the protein kinase A (PKA) pathway as well as rapid internalization and vacuolar breakdown of Pho84...

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Bibliographic Details
Published in:	Biochemistry (Easton) Vol. 48; no. 21; pp. 4497 - 4505
Main Authors:	Lundh, Fredrik, Mouillon, Jean-Marie, Samyn, Dieter, Stadler, Kent, Popova, Yulia, Lagerstedt, Jens O, Thevelein, Johan M, Persson, Bengt L
Format:	Journal Article
Language:	English
Published:	United States 02.06.2009
Subjects:	Cyclic AMP-Dependent Protein Kinases - metabolism Down-Regulation - drug effects Feedback, Physiological Intracellular Space - metabolism Phosphates - metabolism Phosphates - pharmacology Phosphorylation - drug effects Protein Transport - drug effects Proton-Phosphate Symporters - chemistry Proton-Phosphate Symporters - metabolism Saccharomyces cerevisiae - cytology Saccharomyces cerevisiae - drug effects Saccharomyces cerevisiae - metabolism Saccharomyces cerevisiae Proteins - chemistry Saccharomyces cerevisiae Proteins - metabolism Signal Transduction - drug effects Ubiquitin - metabolism Up-Regulation - drug effects
ISSN:	1520-4995
Online Access:	Get more information
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