In situ Sensing of Single Binding Events by Localized Surface Plasmon Resonance

Single binding events of nanoparticle-labeled DNA strands were detected as stepwise peak shifts in localized surface plasmon resonance by single particle measurement. We confirmed the number of binding events by observing label particles by scanning electron microscopy. Our simulation based on a mul...

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Bibliographic Details
Published in:Nano letters Vol. 8; no. 10; pp. 3450 - 3455
Main Authors: Sannomiya, Takumi, Hafner, Christian, Voros, Janos
Format: Journal Article
Language:English
Published: Washington, DC American Chemical Society 01.10.2008
Subjects:
Adsorption
Biocompatible Materials - chemistry
Biosensing Techniques
Computer Simulation
Condensed matter: electronic structure, electrical, magnetic, and optical properties
Cross-disciplinary physics: materials science; rheology
DNA - chemistry
Electron states and collective excitations in thin films, multilayers, quantum wells, mesoscopic and nanoscale systems
Electronic structure and electrical properties of surfaces, interfaces, thin films and low-dimensional structures
Equipment Design
Exact sciences and technology
Kinetics
Materials science
Metal Nanoparticles - chemistry
Microscopy, Electron, Scanning
Nanocrystalline materials
Nanoscale materials and structures: fabrication and characterization
Nanotechnology - methods
Physics
Polyethylene Glycols - chemistry
Polylysine - chemistry
Surface Plasmon Resonance - instrumentation
Surface Plasmon Resonance - methods
Nanoparticles
Scanning electron microscopy
DNA
Digital simulation
Surface plasmon resonance
Gallium phosphide
Nanostructured materials
ISSN:1530-6984, 1530-6992
Online Access:Get full text
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Summary:Single binding events of nanoparticle-labeled DNA strands were detected as stepwise peak shifts in localized surface plasmon resonance by single particle measurement. We confirmed the number of binding events by observing label particles by scanning electron microscopy. Our simulation based on a multiple multipole program showed that the peak shift is dependent on interparticle gap size and binding position. The experimental peak shift distribution was also reproduced by simulation.
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ISSN:1530-6984
1530-6992
DOI:10.1021/nl802317d