In situ Sensing of Single Binding Events by Localized Surface Plasmon Resonance

Single binding events of nanoparticle-labeled DNA strands were detected as stepwise peak shifts in localized surface plasmon resonance by single particle measurement. We confirmed the number of binding events by observing label particles by scanning electron microscopy. Our simulation based on a mul...

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Vydáno v:Nano letters Ročník 8; číslo 10; s. 3450 - 3455
Hlavní autoři: Sannomiya, Takumi, Hafner, Christian, Voros, Janos
Médium: Journal Article
Jazyk:angličtina
Vydáno: Washington, DC American Chemical Society 01.10.2008
Témata:
Adsorption
Biocompatible Materials - chemistry
Biosensing Techniques
Computer Simulation
Condensed matter: electronic structure, electrical, magnetic, and optical properties
Cross-disciplinary physics: materials science; rheology
DNA - chemistry
Electron states and collective excitations in thin films, multilayers, quantum wells, mesoscopic and nanoscale systems
Electronic structure and electrical properties of surfaces, interfaces, thin films and low-dimensional structures
Equipment Design
Exact sciences and technology
Kinetics
Materials science
Metal Nanoparticles - chemistry
Microscopy, Electron, Scanning
Nanocrystalline materials
Nanoscale materials and structures: fabrication and characterization
Nanotechnology - methods
Physics
Polyethylene Glycols - chemistry
Polylysine - chemistry
Surface Plasmon Resonance - instrumentation
Surface Plasmon Resonance - methods
Nanoparticles
Scanning electron microscopy
DNA
Digital simulation
Surface plasmon resonance
Gallium phosphide
Nanostructured materials
ISSN:1530-6984, 1530-6992
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Shrnutí:Single binding events of nanoparticle-labeled DNA strands were detected as stepwise peak shifts in localized surface plasmon resonance by single particle measurement. We confirmed the number of binding events by observing label particles by scanning electron microscopy. Our simulation based on a multiple multipole program showed that the peak shift is dependent on interparticle gap size and binding position. The experimental peak shift distribution was also reproduced by simulation.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
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content type line 23
ISSN:1530-6984
1530-6992
DOI:10.1021/nl802317d