Synergistic Activity of Clofazimine and Clarithromycin in an Aerosol Mouse Model of Mycobacterium avium Infection

Infections with nontuberculous mycobacteria (NTM) have a poor prognosis in patients with underlying respiratory diseases. Clofazimine (CFZ) showed both experimental and clinical promising results against clinically relevant NTM. However, there are no data on CFZ in combination with the current recom...

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Bibliographic Details
Published in:	Antimicrobial agents and chemotherapy Vol. 64; no. 5
Main Authors:	Lanoix, Jean-Philippe, Joseph, Cédric, Peltier, François, Castelain, Sandrine, Andréjak, Claire
Format:	Journal Article
Language:	English
Published:	United States 21.04.2020
Subjects:	Aerosols Animals Antitubercular Agents - administration & dosage Antitubercular Agents - therapeutic use Clarithromycin - administration & dosage Clarithromycin - therapeutic use Clofazimine - pharmacology Clofazimine - therapeutic use Colony Count, Microbial Drug Synergism Ethambutol - therapeutic use Female Lung - microbiology Mice Mice, Inbred BALB C Microbial Sensitivity Tests Mycobacterium avium - drug effects Mycobacterium avium-intracellulare Infection - drug therapy Mycobacterium avium-intracellulare Infection - microbiology Rifampin - therapeutic use Treatment Outcome Mycobacterium avium treatment clofazimine mouse model
ISSN:	1098-6596, 1098-6596
Online Access:	Get more information
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