Synergistic Activity of Clofazimine and Clarithromycin in an Aerosol Mouse Model of Mycobacterium avium Infection

Infections with nontuberculous mycobacteria (NTM) have a poor prognosis in patients with underlying respiratory diseases. Clofazimine (CFZ) showed both experimental and clinical promising results against clinically relevant NTM. However, there are no data on CFZ in combination with the current recom...

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Veröffentlicht in:	Antimicrobial agents and chemotherapy Jg. 64; H. 5
Hauptverfasser:	Lanoix, Jean-Philippe, Joseph, Cédric, Peltier, François, Castelain, Sandrine, Andréjak, Claire
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 21.04.2020
Schlagworte:	Aerosols Animals Antitubercular Agents - administration & dosage Antitubercular Agents - therapeutic use Clarithromycin - administration & dosage Clarithromycin - therapeutic use Clofazimine - pharmacology Clofazimine - therapeutic use Colony Count, Microbial Drug Synergism Ethambutol - therapeutic use Female Lung - microbiology Mice Mice, Inbred BALB C Microbial Sensitivity Tests Mycobacterium avium - drug effects Mycobacterium avium-intracellulare Infection - drug therapy Mycobacterium avium-intracellulare Infection - microbiology Rifampin - therapeutic use Treatment Outcome Mycobacterium avium treatment clofazimine mouse model
ISSN:	1098-6596, 1098-6596
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