Identification and Characterization of BMS-955176, a Second-Generation HIV-1 Maturation Inhibitor with Improved Potency, Antiviral Spectrum, and Gag Polymorphic Coverage

BMS-955176 is a second-generation human immunodeficiency virus type 1 (HIV-1) maturation inhibitor (MI). A first-generation MI, bevirimat, showed clinical efficacy in early-phase studies, but ∼50% of subjects had viruses with reduced susceptibility associated with naturally occurring polymorphisms i...

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Veröffentlicht in:	Antimicrobial agents and chemotherapy Jg. 60; H. 7; S. 3956
Hauptverfasser:	Nowicka-Sans, Beata, Protack, Tricia, Lin, Zeyu, Li, Zhufang, Zhang, Sharon, Sun, Yongnian, Samanta, Himadri, Terry, Brian, Liu, Zheng, Chen, Yan, Sin, Ny, Sit, Sing-Yuen, Swidorski, Jacob J, Chen, Jie, Venables, Brian L, Healy, Matthew, Meanwell, Nicholas A, Cockett, Mark, Hanumegowda, Umesh, Regueiro-Ren, Alicia, Krystal, Mark, Dicker, Ira B
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 01.07.2016
Schlagworte:	Anti-HIV Agents - pharmacology Drug Resistance, Viral - genetics gag Gene Products, Human Immunodeficiency Virus - antagonists & inhibitors HIV-1 - drug effects HIV-1 - metabolism Humans Succinates - pharmacology Triterpenes - pharmacology Virus Replication - drug effects
ISSN:	1098-6596, 1098-6596
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