Fluorinating the Sugar and the Nucleotide: Exploring Fluorination Within GDP-Mannose Probes Using Chemoenzymatic Synthesis

Fluorinated glycans offer a prime opportunity to study the intricacies of their associated binding events with proteins, invoke resistance toward enzymatic hydrolysis, and modulate carbohydrate physicochemical properties. Sugar nucleotides are the key building blocks used by glycosyltransferases and...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	JACS Au Jg. 5; H. 8; S. 3994 - 4001
Hauptverfasser:	Dolan, Jonathan P., Evans, Sean T., Benckendorff, Caecilie M. M., Sari, Suat, Ní Cheallaigh, Aisling, Miller, Gavin J.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States American Chemical Society 25.08.2025
Schlagworte:	fluorination chemical probe glycan sugar nucleotide dehydrogenase
ISSN:	2691-3704, 2691-3704
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!