Discovery and Structure-Activity Relationships of the Neoseptins: A New Class of Toll-like Receptor-4 (TLR4) Agonists

Herein, we report studies leading to the discovery of the neoseptins and a comprehensive examination of the structure activity relationships (SARs) of this new class of small-molecule mouse Toll-like receptor 4 (mTLR4) agonists. The compounds in this class, which emerged from screening an a-helix mi...

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Vydáno v:	Journal of medicinal chemistry Ročník 59; číslo 10; s. 4812 - 4830
Hlavní autoři:	Morin, Matthew D., Wang, Ying, Jones, Brian T., Su, Lijing, Surakattula, Murali M. R. P., Berger, Michael, Huang, Hua, Beutler, Elliot K., Zhang, Hong, Beutler, Bruce, Boger, Dale L.
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	WASHINGTON Amer Chemical Soc 26.05.2016
Témata:	Aminobutyrates - chemical synthesis Aminobutyrates - chemistry Aminobutyrates - pharmacology Animals Benzamides - chemical synthesis Benzamides - chemistry Benzamides - pharmacology Chemistry, Medicinal Dose-Response Relationship, Drug Drug Discovery Humans Life Sciences & Biomedicine Mice Mice, Inbred C57BL Models, Molecular Molecular Structure Ovalbumin - immunology Pharmacology & Pharmacy Science & Technology Structure-Activity Relationship Toll-Like Receptor 4 - agonists ADAPTIVE IMMUNITY MONOPHOSPHORYL-LIPID-A ACTIVATION ENDOTOXIN ANTAGONIST BINDING-PROTEIN TLR4-MD-2 COMPLEX VACCINE ADJUVANTS TARGETING PROTEIN-PROTEIN LPS INNATE IMMUNITY
ISSN:	0022-2623, 1520-4804, 1520-4804
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