Genetic variants associated with phenytoin-related severe cutaneous adverse reactions

The antiepileptic drug phenytoin can cause cutaneous adverse reactions, ranging from maculopapular exanthema to severe cutaneous adverse reactions, which include drug reactions with eosinophilia and systemic symptoms, Stevens-Johnson syndrome, and toxic epidermal necrolysis. The pharmacogenomic basi...

Celý popis

Uloženo v:

Podrobná bibliografie
Vydáno v:	JAMA : the journal of the American Medical Association Ročník 312; číslo 5; s. 525
Hlavní autoři:	Chung, Wen-Hung, Chang, Wan-Chun, Lee, Yun-Shien, Wu, Ying-Ying, Yang, Chih-Hsun, Ho, Hsin-Chun, Chen, Ming-Jing, Lin, Jing-Yi, Hui, Rosaline Chung-Yee, Ho, Ji-Chen, Wu, Wei-Ming, Chen, Ting-Jui, Wu, Tony, Wu, Yih-Ru, Hsih, Mo-Song, Tu, Po-Hsun, Chang, Chen-Nen, Hsu, Chien-Ning, Wu, Tsu-Lan, Choon, Siew-Eng, Hsu, Chao-Kai, Chen, Der-Yuan, Liu, Chin-San, Lin, Ching-Yuang, Kaniwa, Nahoko, Saito, Yoshiro, Takahashi, Yukitoshi, Nakamura, Ryosuke, Azukizawa, Hiroaki, Shi, Yongyong, Wang, Tzu-Hao, Chuang, Shiow-Shuh, Tsai, Shih-Feng, Chang, Chee-Jen, Chang, Yu-Sun, Hung, Shuen-Iu
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States 06.08.2014
Témata:	Adolescent Adult Aged Aged, 80 and over Anticonvulsants - adverse effects Anticonvulsants - pharmacokinetics Aryl Hydrocarbon Hydroxylases - genetics Case-Control Studies Cytochrome P-450 CYP2C9 Eosinophilia - chemically induced Eosinophilia - genetics Female Genome-Wide Association Study Humans Japan Malaysia Male Middle Aged Pharmacogenetics Phenytoin - adverse effects Phenytoin - pharmacokinetics Polymorphism, Single Nucleotide Stevens-Johnson Syndrome - genetics Taiwan Young Adult Japan Malaysia Taiwan
ISSN:	1538-3598, 1538-3598
On-line přístup:	Zjistit podrobnosti o přístupu
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!

Buďte první, kdo okomentuje tento záznam!