Genetic variants associated with phenytoin-related severe cutaneous adverse reactions

The antiepileptic drug phenytoin can cause cutaneous adverse reactions, ranging from maculopapular exanthema to severe cutaneous adverse reactions, which include drug reactions with eosinophilia and systemic symptoms, Stevens-Johnson syndrome, and toxic epidermal necrolysis. The pharmacogenomic basi...

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Bibliographic Details
Published in:	JAMA : the journal of the American Medical Association Vol. 312; no. 5; p. 525
Main Authors:	Chung, Wen-Hung, Chang, Wan-Chun, Lee, Yun-Shien, Wu, Ying-Ying, Yang, Chih-Hsun, Ho, Hsin-Chun, Chen, Ming-Jing, Lin, Jing-Yi, Hui, Rosaline Chung-Yee, Ho, Ji-Chen, Wu, Wei-Ming, Chen, Ting-Jui, Wu, Tony, Wu, Yih-Ru, Hsih, Mo-Song, Tu, Po-Hsun, Chang, Chen-Nen, Hsu, Chien-Ning, Wu, Tsu-Lan, Choon, Siew-Eng, Hsu, Chao-Kai, Chen, Der-Yuan, Liu, Chin-San, Lin, Ching-Yuang, Kaniwa, Nahoko, Saito, Yoshiro, Takahashi, Yukitoshi, Nakamura, Ryosuke, Azukizawa, Hiroaki, Shi, Yongyong, Wang, Tzu-Hao, Chuang, Shiow-Shuh, Tsai, Shih-Feng, Chang, Chee-Jen, Chang, Yu-Sun, Hung, Shuen-Iu
Format:	Journal Article
Language:	English
Published:	United States 06.08.2014
Subjects:	Adolescent Adult Aged Aged, 80 and over Anticonvulsants - adverse effects Anticonvulsants - pharmacokinetics Aryl Hydrocarbon Hydroxylases - genetics Case-Control Studies Cytochrome P-450 CYP2C9 Eosinophilia - chemically induced Eosinophilia - genetics Female Genome-Wide Association Study Humans Japan Malaysia Male Middle Aged Pharmacogenetics Phenytoin - adverse effects Phenytoin - pharmacokinetics Polymorphism, Single Nucleotide Stevens-Johnson Syndrome - genetics Taiwan Young Adult Japan Malaysia Taiwan
ISSN:	1538-3598, 1538-3598
Online Access:	Get more information
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