Regulation of the Mitochondrion-Fatty Acid Axis for the Metabolic Reprogramming of Chlamydia trachomatis during Treatment with β-Lactam Antimicrobials

The mitochondrion generates most of the ATP in eukaryotic cells, and its activity is used for controlling the intracellular growth of Chlamydia trachomatis . Furthermore, mitochondrial activity is tightly connected to host fatty acid synthesis that is indispensable for chlamydial membrane biogenesis...

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Bibliographic Details
Published in:	mBio Vol. 12; no. 2
Main Authors:	Shima, Kensuke, Kaufhold, Inga, Eder, Thomas, Käding, Nadja, Schmidt, Nis, Ogunsulire, Iretiolu M., Deenen, René, Köhrer, Karl, Friedrich, Dirk, Isay, Sophie E., Grebien, Florian, Klinger, Matthias, Richer, Barbara C., Günther, Ulrich L., Deepe, George S., Rattei, Thomas, Rupp, Jan
Format:	Journal Article
Language:	English
Published:	United States American Society for Microbiology 30.03.2021
Subjects:	Anti-Bacterial Agents - pharmacology Antimicrobial agents Bacterial infections beta-lactams beta-Lactams - pharmacology Chlamydia Chlamydia Infections - drug therapy Chlamydia Infections - microbiology Chlamydia trachomatis Chlamydia trachomatis - drug effects Chlamydia trachomatis - genetics Chlamydia trachomatis - metabolism citrate Cytokines Electron transport Fatty acids Fatty Acids - metabolism HeLa Cells Humans Intracellular Lipids Metabolism Metabolites Mitochondria Mitochondria - drug effects Mitochondria - metabolism Penicillin Persistent infection Phospholipids Phosphorylation Proteins Research Article Respiration Sexually transmitted diseases STAT3 Stat3 protein STAT3 Transcription Factor - genetics STAT3 Transcription Factor - metabolism STD Tricarboxylic acid cycle β-Lactam antibiotics γ-Interferon penicillin beta-lactams citrate fatty acids mitochondria protein tyrosine phosphatase STAT3 persistence Chlamydia trachomatis metabolism
ISSN:	2150-7511, 2161-2129, 2150-7511
Online Access:	Get full text
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