A new class of symmetric bisbenzimidazole-based DNA minor groove-binding agents showing antitumor activity

The synthesis and evaluation of the novel head-to-head bisbenzimidazole compound 2,2-bis[4'-(3 " -dimethylamino- 1 " -propyloxy)phenyl]-5,5-bi-1H-benzimidazole is described. An X-ray crystallographic study of a complex with the DNA dodecanucleotide sequence d(CGCGAATTCGCG) shows the c...

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Veröffentlicht in:	Journal of medicinal chemistry Jg. 44; H. 2; S. 138 - 144
Hauptverfasser:	Mann, J, Baron, A, Opoku-Boahen, Y, Johansson, E, Parkinson, G, Kelland, LR, Neidle, S
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	WASHINGTON Amer Chemical Soc 18.01.2001
Schlagworte:	Animals Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Benzimidazoles - chemical synthesis Benzimidazoles - chemistry Benzimidazoles - metabolism Benzimidazoles - pharmacology Chemistry, Medicinal Cisplatin - pharmacology Crystallography, X-Ray DNA - metabolism Drug Resistance, Neoplasm Drug Screening Assays, Antitumor Female Humans Life Sciences & Biomedicine Magnetic Resonance Spectroscopy Mass Spectrometry Mice Mice, Nude Models, Molecular Pharmacology & Pharmacy Science & Technology Structure-Activity Relationship Transplantation, Heterologous Tumor Cells, Cultured PROTEIN BINDER RECOGNITION CRYSTAL-STRUCTURE DRUGS TOPOISOMERASE-I D(CGCGAATTCGCG)2 DERIVATIVES HOECHST 33258
ISSN:	0022-2623, 1520-4804
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