A new class of symmetric bisbenzimidazole-based DNA minor groove-binding agents showing antitumor activity

The synthesis and evaluation of the novel head-to-head bisbenzimidazole compound 2,2-bis[4'-(3 " -dimethylamino- 1 " -propyloxy)phenyl]-5,5-bi-1H-benzimidazole is described. An X-ray crystallographic study of a complex with the DNA dodecanucleotide sequence d(CGCGAATTCGCG) shows the c...

Full description

Saved in:

Bibliographic Details
Published in:	Journal of medicinal chemistry Vol. 44; no. 2; pp. 138 - 144
Main Authors:	Mann, J, Baron, A, Opoku-Boahen, Y, Johansson, E, Parkinson, G, Kelland, LR, Neidle, S
Format:	Journal Article
Language:	English
Published:	WASHINGTON Amer Chemical Soc 18.01.2001
Subjects:	Animals Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Benzimidazoles - chemical synthesis Benzimidazoles - chemistry Benzimidazoles - metabolism Benzimidazoles - pharmacology Chemistry, Medicinal Cisplatin - pharmacology Crystallography, X-Ray DNA - metabolism Drug Resistance, Neoplasm Drug Screening Assays, Antitumor Female Humans Life Sciences & Biomedicine Magnetic Resonance Spectroscopy Mass Spectrometry Mice Mice, Nude Models, Molecular Pharmacology & Pharmacy Science & Technology Structure-Activity Relationship Transplantation, Heterologous Tumor Cells, Cultured PROTEIN BINDER RECOGNITION CRYSTAL-STRUCTURE DRUGS TOPOISOMERASE-I D(CGCGAATTCGCG)2 DERIVATIVES HOECHST 33258
ISSN:	0022-2623, 1520-4804
Online Access:	Get more information
Tags:	Add Tag No Tags, Be the first to tag this record!

Be the first to leave a comment!