LP(a): Structure, Genetics, Associated Cardiovascular Risk, and Emerging Therapeutics

Lipoprotein(a) [Lp(a)] is a molecule bound to apolipoprotein(a) with some similarity to low-density lipoprotein cholesterol (LDL-C), which has been found to be a risk factor for cardiovascular disease (CVD). Lp(a) appears to induce inflammation, atherogenesis, and thrombosis. Approximately 20% of th...

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Veröffentlicht in:	Annual review of pharmacology and toxicology Jg. 64; S. 135
Hauptverfasser:	Tasdighi, Erfan, Adhikari, Rishav, Almaadawy, Omar, Leucker, Thorsten M, Blaha, Michael J
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 23.01.2024
Schlagworte:	Cardiovascular Diseases - drug therapy Cardiovascular Diseases - genetics Cholesterol, LDL - metabolism Cholesterol, LDL - therapeutic use Heart Disease Risk Factors Humans Lipoprotein(a) - genetics Lipoprotein(a) - metabolism Lipoprotein(a) - therapeutic use Risk Factors atherosclerosis clinical trial cardiovascular disease lipoprotein(a) therapy antisense oligonucleotides
ISSN:	1545-4304, 1545-4304
Online-Zugang:	Weitere Angaben
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