Coffee, Caffeine, and Health Outcomes: An Umbrella Review

To evaluate the associations between coffee and caffeine consumption and various health outcomes, we performed an umbrella review of the evidence from meta-analyses of observational studies and randomized controlled trials (RCTs). Of the 59 unique outcomes examined in the selected 112 meta-analyses...

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Bibliographic Details
Published in:Annual review of nutrition Vol. 37; p. 131
Main Authors: Grosso, Giuseppe, Godos, Justyna, Galvano, Fabio, Giovannucci, Edward L
Format: Journal Article
Language:English
Published: United States 21.08.2017
Subjects:
Caffeine - pharmacology
Cardiovascular Diseases - epidemiology
Coffee
Diabetes Mellitus, Type 2 - epidemiology
Female
Humans
Male
Neoplasms - epidemiology
Neurodegenerative Diseases - epidemiology
Observational Studies as Topic
Pregnancy
Randomized Controlled Trials as Topic
Risk
cardiovascular disease
caffeine
cancer
neurodegenerative disease
diabetes
coffee
ISSN:1545-4312, 1545-4312
Online Access:Get more information
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Summary:To evaluate the associations between coffee and caffeine consumption and various health outcomes, we performed an umbrella review of the evidence from meta-analyses of observational studies and randomized controlled trials (RCTs). Of the 59 unique outcomes examined in the selected 112 meta-analyses of observational studies, coffee was associated with a probable decreased risk of breast, colorectal, colon, endometrial, and prostate cancers; cardiovascular disease and mortality; Parkinson's disease; and type-2 diabetes. Of the 14 unique outcomes examined in the 20 selected meta-analyses of observational studies, caffeine was associated with a probable decreased risk of Parkinson's disease and type-2 diabetes and an increased risk of pregnancy loss. Of the 12 unique acute outcomes examined in the selected 9 meta-analyses of RCTs, coffee was associated with a rise in serum lipids, but this result was affected by significant heterogeneity, and caffeine was associated with a rise in blood pressure. Given the spectrum of conditions studied and the robustness of many of the results, these findings indicate that coffee can be part of a healthful diet.
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ISSN:1545-4312
1545-4312
DOI:10.1146/annurev-nutr-071816-064941