Amylin proprotein processing generates progressively more amyloidogenic peptides that initially sample the helical state

Human amylin, or islet amyloid polypeptide, is a peptide cosecreted with insulin by the beta cells of the pancreatic islets of Langerhans. The 37-residue, C-terminally amidated human amylin peptide derives from a proprotein that undergoes disulfide bond formation in the endoplasmic reticulum and is...

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Veröffentlicht in:	Biochemistry (Easton) Jg. 47; H. 37; S. 9900
Hauptverfasser:	Yonemoto, Isaac T, Kroon, Gerard J A, Dyson, H Jane, Balch, William E, Kelly, Jeffery W
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 16.09.2008
Schlagworte:	Amino Acid Sequence Amyloid - chemical synthesis Amyloid - chemistry Amyloid - metabolism Chromatography, Gel Circular Dichroism Humans Islet Amyloid Polypeptide Kinetics Molecular Sequence Data Nuclear Magnetic Resonance, Biomolecular
ISSN:	1520-4995, 1520-4995
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