Regulation of Selenium Metabolism and Transport

Selenium is regulated in the body to maintain vital selenoproteins and to avoid toxicity. When selenium is limiting, cells utilize it to synthesize the selenoproteins most important to them, creating a selenoprotein hierarchy in the cell. The liver is the central organ for selenium regulation and pr...

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Podrobná bibliografia
Vydané v:	Annual review of nutrition Ročník 35; s. 109 - 134
Hlavní autori:	Burk, Raymond F, Hill, Kristina E
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 17.07.2015
Predmet:	Animals Biological Availability Biological Transport Biomarkers Diet Dietary Supplements Health Status Homeostasis - physiology Humans Kidney Tubules, Proximal - metabolism LDL-Receptor Related Proteins - physiology Liver - physiology Low Density Lipoprotein Receptor-Related Protein-2 - physiology Nutritional Requirements Organ Specificity Selenium - deficiency Selenium - metabolism Selenium - pharmacokinetics Selenocysteine - metabolism Selenomethionine - metabolism Selenoprotein P - analysis Selenoprotein P - blood Selenoproteins - biosynthesis Selenoproteins - metabolism selenocysteine lyase human selenium metabolism apolipoprotein E receptor-2 selenoprotein hierarchy megalin selenoprotein P
ISSN:	1545-4312
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Popis
Shrnutí:	Selenium is regulated in the body to maintain vital selenoproteins and to avoid toxicity. When selenium is limiting, cells utilize it to synthesize the selenoproteins most important to them, creating a selenoprotein hierarchy in the cell. The liver is the central organ for selenium regulation and produces excretory selenium forms to regulate whole-body selenium. It responds to selenium deficiency by curtailing excretion and secreting selenoprotein P (Sepp1) into the plasma at the expense of its intracellular selenoproteins. Plasma Sepp1 is distributed to tissues in relation to their expression of the Sepp1 receptor apolipoprotein E receptor-2, creating a tissue selenium hierarchy. N-terminal Sepp1 forms are taken up in the renal proximal tubule by another receptor, megalin. Thus, the regulated whole-body pool of selenium is shifted to needy cells and then to vital selenoproteins in them to supply selenium where it is needed, creating a whole-body selenoprotein hierarchy.
Bibliografia:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-2
ISSN:	1545-4312
DOI:	10.1146/annurev-nutr-071714-034250